Peer-reviewed findings with their methods and gaps named — the distance between paper and.
U.S. synthetic DNA biosecurity rests on a voluntary screening framework issued by the Department of Health and Human Services in October 2023, which asks gene synthesis providers and their customers to screen orders for sequences of concern down to 50 nucleotides, per the guidance published by…
A Phase 1 trial of CTX310, a lipid-nanoparticle-delivered CRISPR-Cas9 therapy targeting ANGPTL3, produced dose-dependent lipid reductions in 15 adults with uncontrolled dyslipidemia, per the study published in the New England Journal of Medicine in November 2025. At the highest dose, circulating…
An organoid is a three-dimensional cell culture, grown from stem cells or tissue progenitors, that self-organizes into a miniature version of an organ’s architecture and functions. Protocol advances have produced organ-like structures displaying the morphological and functional characteristics…
Basic research in the United States is funded mainly through competitive grants, cooperative agreements, and fellowships, a structure the National Science Foundation describes as hundreds of funding opportunities across science and engineering. The benchmark instrument is NIH's R01, which the…
Biomedical findings fail to replicate for structural reasons — small studies, flexible analyses and selective reporting — first formalized in a 2005 PLOS Medicine essay arguing most research claims are more likely false than true. The institutional response has been funder policy, notably NIH's…